유효성 평가
의약품, 식품첨가물, 건강기능식품 등의 생리학적 작용과 효능 판단 시험입니다.
CNS 관련 시험
투여 경로 및 방법
Cells transplantation in brain using stereotaxic
Drug injection
- Oral administration
- Intraperitoneal administration
- Intravenous administration
분석 방법 1. Survival and differentiation of transplanted cells
Immunostaining (IF and IHC)
분석 방법 2. 신경 보호 효과
Inflammation and anti-inflammation
- Immunostaining (IF and IHC)
- Western blot
Degeneration of motor neurons
- Immunostaining (IF and IHC)
- Western blot
분석 방법 3. 행동 테스트
Motor function
- Rotarod Test
- Treadmill Test
- Grip Strength Test (GST)
- Pole Test
- Beam Balance Test
- Clasping Test
- Gait analysis
Cognition and Memory function
- Y-maze Test
- Morris Water Maze Test
- Barnes Maze Test
- Novel Object Recognition Test
- Simple Swimming Test
- Passive Avoidance Test
Emotion function
- Open Field Test
- Forced Swim Test (depression)
- Elevated plus maze
Pain
- Von Frey Test
Gait analysis
