유효성 평가

의약품, 식품첨가물, 건강기능식품 등의 생리학적 작용과 효능 판단 시험입니다.

안과 시험

Ocular Disease model
Laser induced CNV model(Wet AMD model)
  • Image-guided OCT / funduscopy
  • Electroretinography
  • Immunohistochemistry
  • Further optional evaluation
Blue LED induced damage(Dry AMD model)
  • Image-guided OCT / funduscopy
  • Electroretinography
  • Immunohistochemistry
  • Further optional evaluation
Dry AMD rat model
  • Cytokine: TNF-α, IL-1β, IL-6 (serum ELISA)
  • Antioxidant factor : TAC, SOD, CAT, GSH-Px (serum ELISA)
  • Anti-inflammatory factor : MDA (serum ELISA)
  • Retinal damage : NF-kB, Nrf-2, HO-1 (Retina qPCR)
  • Histology : ONL thickness, ONL nuclear number, Photoreceptor thickness
Sodium Iodate-induced RD model
  • Electroretinography
  • Image-guided OCT / funduscopy
  • Immunohistochemistry
MNU-induced RD model
  • Electroretinography
  • Image-guided OCT / funduscopy
  • Immunohistochemistry
Humanized RS1-mut mouse model
Diabetic Retinopathy model
  • Image-guided OCT / funduscopy
  • PhNR, pattern ERG
  • Immunohistochemistry
  • Quantification of ganglion cell loss
Retinal Detachment model
  • Image-guided OCT / funduscopy
  • ERG
  • H&E Staining
  • Immunohistochemistry
Glaucoma model
  • Image-guided OCT / funduscopy
  • PhNR, pattern ERG
  • Immunohistochemistry
  • Quantification of ganglion cell loss
Scopolamine induced dry eye mouse model
BAC induced dry eye rabbit model
Presbyopia (Lens Elasticity study)
Ocular PK/PD

System

A novel analysis of ERG responses optimized for mouse retinal function

A whole-mount technology uniquely enabled by our proprietary core innovation

Histology evaluation in non-separate sclerochoroid/retina pigment epithelium/retina whole mounts from C57/BL6 mouse

A new method of pigment bleaching RPE / Retina whole mount to observe intact subretinal space